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The 2018 paper in Biochemical Pharmacology gave obese mice a membrane-permeable NNMT inhibitor and reported it significantly reduced body weight and white adipose mass, decreased adipocyte size, with the mice eating the same amount as before, and the authors noting the inhibitors did not impact total food intake nor produce any observable adverse effects [1]

Switching up where you inject helps avoid soreness and ensures the shot works well

Most patients notice improvements within 2-4 weeks, but if youre not seeing changes, we pivot the approach until we find what works